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Compare PN Healer, Eye, S, and HB. Doctor-led injectable treatment with Dr Samantha Tay at Nexus Aesthetic. Session schedule, aftercare, and consultation details below.
polynucleotide skin booster is an injectable skin booster made from salmon-derived polynucleotides, short DNA fragments that work deeper than creams and serums can reach. Once injected, the fragments support the skin's own repair signals, helping the collagen-producing cells (called fibroblasts) stay active.
Unlike hyaluronic acid fillers that add volume, polynucleotide skin booster works at the cellular level. It is used to improve skin texture, hydration, elasticity, and the appearance of fine lines. Developed in South Korea and widely administered across Singapore aesthetic clinics, it has become one of the go-to injectable treatments for patients who want regenerative, non-surgical skin rejuvenation.
Your skin makes less collagen each year after age 25. polynucleotide skin booster's salmon DNA fragments act as a signal that switches on the repair cells in your skin, helping them produce fresh collagen and hold water better. Results build over several weeks as your skin remodels from within.
Each polynucleotide variants has a different formula tuned for a specific concern. Dr Samantha advises on the right variant during consultation.
Classic formula for overall skin quality: elasticity, hydration, fine lines. The most common first-time polynucleotide skin booster treatment.
Lower-concentration, more fluid formula designed for thin under-eye skin. Helps with dark circles, fine lines, and puffiness without causing lumps.
Higher-concentration formula for localised scarring. Used directly on acne scars, post-inflammatory texture, and stretch-mark areas.
Combines polynucleotide with hyaluronic acid for immediate hydration on top of the regenerative effect. Often chosen for skin glow.
The right variant depends on the concern, skin type, and treatment area. Dr Samantha assesses all three during consultation and recommends the combination that matches your goals.
| Your concern | Recommended variant |
|---|---|
| Full-face skin quality, elasticity, fine lines | PN Healer |
| Dark eye circles, under-eye fine lines, puffiness | PN Eye (PN I) |
| Acne scarring, post-inflammatory texture | PN S |
| Deep hydration combined with anti-ageing | PN HB+ |
| Combination of the above | Combined protocol, discussed during consultation |
polynucleotide skin booster fees at Nexus are doctor-administered and variant-specific. The figure for PN Healer below is a starting point. Fees for polynucleotide skin booster Eye, S, and HB depend on the variant and the number of sessions your skin plan calls for, and are confirmed during consultation with Dr Samantha.
Nexus does not publish introductory or first-time-only offers. Every fee is confirmed after a medical assessment, based on the variant chosen and your individual session plan.
Skin feels more hydrated. Mild redness, swelling, or small bumps at injection sites are common and usually settle within 24 to 48 hours.
Hydration and texture improvements become noticeable. Skin feels smoother to the touch.
Further improvements in firmness and elasticity as the skin remodels from within. Individual results vary.
Results typically hold in most patients. Some combine polynucleotide skin booster with other treatments for layered effect.
Maintenance sessions are typically recommended to sustain results. Frequency depends on the variant used.
A typical polynucleotide skin booster session takes under an hour end-to-end.
Dr Samantha reviews your skin, medical history, and goals. The right variant and session count are chosen based on this assessment.
Applied for 30 to 45 minutes before injection to minimise discomfort.
Small amounts are injected into the target area using fine needles. The injection step takes 15 to 20 minutes.
Dr Samantha walks you through aftercare before you leave the clinic.
Suitability is assessed during consultation. Dr Samantha reviews your medical history in detail before any treatment decision.
Dr Samantha graduated from the National University of Singapore with an MBBS in 2013 and completed four years of surgical rotations at KKH Hospital before transitioning to aesthetic medicine.
With more than ten years of aesthetic practice, she has performed thousands of polynucleotide-based treatments. All polynucleotide skin booster sessions at Nexus are performed by Dr Samantha personally, from initial consultation through to final injection and follow-up.
If you have persistent skin concerns that topical products have not addressed, a medical consultation is the right next step. Dr Samantha assesses suitability for polynucleotide skin booster and other bio-regenerative options based on your individual history, not a template plan.
PN Healer starts from $299 per session at Nexus Aesthetic, inclusive of the initial medical assessment with Dr Samantha. Pricing for PN Eye, S, and HB depends on the variant and session count and is discussed during consultation. Contact the clinic for updated treatment package pricing.
Yes. polynucleotide skin booster is the brand name. Polynucleotide skin booster is the product category. When Singapore clinics say PN skin booster or PDRN injection, they are usually referring to a polynucleotide skin booster-family product or another polynucleotide brand.
Hyaluronic acid fillers add volume. Profhilo is a bio-remodeller that hydrates and improves elasticity using hyaluronic acid. polynucleotide skin booster works on a different mechanism, polynucleotide fragments that support the skin's own collagen-producing cells. Each plays a different role, and they are sometimes combined depending on the patient's goals.
Yes. PN Eye (PN I) is formulated specifically for the delicate under-eye area. It helps with fine lines, dark circles, and puffiness while being gentle enough to avoid the lumps that can occur when fuller-viscosity injectables are placed too close to the surface. See Nexus's dark eye circle treatment page for more detail.
Most patients complete three to four sessions spaced three to four weeks apart, depending on the variant. PN Eye typically needs two to three sessions. PN S for scars typically needs three to five. Dr Samantha advises on the exact protocol during consultation.
Discomfort is generally minimal. Numbing cream is applied for 30 to 45 minutes before injection. Most patients describe the sensation as a series of small pinches rather than pain.
In most patients, results hold for six to twelve months after a completed treatment course. Maintenance sessions are typically recommended to sustain results. Individual response varies with age, skin condition, lifestyle, and the variant used.
Initial hydration and texture changes are often visible within one to two weeks. Further improvement in firmness and fine lines typically develops over the four to six weeks after each session, as the skin remodels from within. Individual timelines vary.
polynucleotide skin booster products are registered with the Health Sciences Authority (HSA) in Singapore and administered under medical supervision. Side effects are typically mild and short-lived: redness, small bumps, and mild swelling at injection sites that resolve within 24 to 48 hours. A full medical history review during consultation flags anyone for whom polynucleotide skin booster is not suitable.
Often yes. Some patients combine polynucleotide skin booster with Profhilo, HA fillers, or tear-trough filler depending on their specific concerns. Dr Samantha advises on combinations during consultation.
Each variant has a different polynucleotide concentration and formula. Healer is the classic full-face product. Eye (PN I) is thinner and lower-concentration for under-eye skin. S is higher-concentration for scars. HB combines polynucleotide with hyaluronic acid for hydration. See the Types section above for a head-to-head comparison.
Minimal. Small bumps at injection sites typically settle within 24 hours. Mild redness may persist for a day or two. Most patients return to normal activities immediately, with the aftercare exceptions listed above (no strenuous exercise, no retinoids) for 48 hours.
